FITC标记的神经颗粒素抗体
产品名称： FITC标记的神经颗粒素抗体
英文名称： Anti-Neurogranin/FITC
产品编号： HZ-11435R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-Neurogranin/FITC Conjugated antibody
FITC标记的神经颗粒素抗体
| 产品编号 | bs-11435R-FITC |
| 英文名称 | Anti-Neurogranin/FITC |
| 中文名称 | FITC标记的神经颗粒素抗体 |
| 别 名 | Calmodulin binding protein; Hng; NEUG(55-78); NEUG_HUMAN; Neurogranin (protein kinase C substrate); Ng; NG; NRGN; Protein kinase C substrate; RC3; BICKS. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 7.6kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NG/Neurogranin (30-78aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq, Jul 2008]. Function: Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium. Tissue Specificity: In the cerebral cortex, found in the cell bodies of neurons in layers II-VI, and in apical and basal dendrites of pyramidal neurons. Is not found in the dendrites in patients with Alzheimer disease. Post-translational modifications: Phosphorylated at Ser-36 by PHK Similarity: Belongs to the neurogranin family. Contains 1 collagen-like domain. Contains 1 IQ domain. Database links: Entrez Gene: 616955 Cow Entrez Gene: 4900 Human Entrez Gene: 64011 Mouse Entrez Gene: 64356 Rat Omim: 602350 Human SwissProt: P35722 Cow SwissProt: Q92686 Human SwissProt: P60761 Mouse SwissProt: Q04940 Rat Unigene: 524116 Human Unigene: 335065 Mouse Unigene: 11236 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Neurogranin（NRGN）是神经元特异性大鼠RC3/神经颗粒蛋白基因的人类同源物。该基因编码一个突触后蛋白激酶底物，结合钙调素在没有钙。NRGN基因含有四个外显子和三个内含子。外显子1和2编码蛋白质和外显子3和4包含非翻译序列。提示NRGN是人脑中甲状腺激素的直接靶点，这种基因表达的控制可以在发育过程中以及成年受试者中表现出甲状腺功能减退对精神状态的许多后果。